Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo
Identifieur interne : 000667 ( Main/Exploration ); précédent : 000666; suivant : 000668Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo
Auteurs : Neal Prakash [États-Unis] ; Susana Cohen-Cory ; Ron D. Frostig [États-Unis]Source :
- Nature [ 0028-0836 ] ; 1996-06-20.
Abstract
THE adult cortex is thought to undergo plastic changes that are closely dependent on neuronal activity (reviewed in ref. 1), although it is not yet known what molecules are involved. Neurotrophins and their receptors have been implicated in several aspects of developmental plasticity24, and their expression in the adult cortex suggests additional roles in adult plasticity59. To examine these potential roles in vivo, we used intrinsic-signal optical imaging to quantify the effects of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) on the functional representation of a stimulated whisker in the 'barrel' subdivision of the rat somatosensory cortex. Topical application of BDNF resulted in a rapid and long-lasting decrease in the size of a whisker representation, and a decrease in the amplitude of the activity-dependent intrinsic signal. In contrast, NGF application resulted in a rapid but transient increase in the size of a representation, and an increase in the amplitude of the activity-dependent intrinsic signal. These results demonstrate that neurotrophins can rapidly modulate stimulus-dependent activity in adult cortex, and suggest a role for neurotrophins in regulating adult cortical plasticity.
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DOI: 10.1038/381702a0
Affiliations:
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Rapid and opposite effects of BDNF and NGF on the functional organization of the adult cortex in vivo</title><author><name sortKey="Prakash, Neal" sort="Prakash, Neal" uniqKey="Prakash N" first="Neal" last="Prakash">Neal Prakash</name></author><author><name sortKey="Cohen Cory, Susana" sort="Cohen Cory, Susana" uniqKey="Cohen Cory S" first="Susana" last="Cohen-Cory">Susana Cohen-Cory</name></author><author><name sortKey="Frostig, Ron D" sort="Frostig, Ron D" uniqKey="Frostig R" first="Ron D." last="Frostig">Ron D. 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Frostig</name><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Department of Psychobiology and the Center for Learning and Memory, University of California at Irvine, Irvine, California 92717, USA Division of Biology, Caltech, Pasadena, California 91125, USA Present address: Mental Retardation Research Center, University of California Los Angeles, School of Medicine, Los Angeles, California 90024</wicri:regionArea><wicri:noRegion>California 90024</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Nature</title><idno type="ISSN">0028-0836</idno><imprint><publisher>Nature Publishing Group</publisher><date type="published" when="1996-06-20">1996-06-20</date><biblScope unit="volume">381</biblScope><biblScope unit="issue">6584</biblScope><biblScope unit="page" from="702">702</biblScope><biblScope unit="page" to="706">706</biblScope></imprint><idno type="ISSN">0028-0836</idno></series><idno type="istex">B1E95B63F22704C02C1FD280553F448C6A83FB0D</idno><idno type="DOI">10.1038/381702a0</idno><idno type="ArticleID">381702a0</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-0836</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">THE adult cortex is thought to undergo plastic changes that are closely dependent on neuronal activity (reviewed in ref. 1), although it is not yet known what molecules are involved. Neurotrophins and their receptors have been implicated in several aspects of developmental plasticity24, and their expression in the adult cortex suggests additional roles in adult plasticity59. To examine these potential roles in vivo, we used intrinsic-signal optical imaging to quantify the effects of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) on the functional representation of a stimulated whisker in the 'barrel' subdivision of the rat somatosensory cortex. Topical application of BDNF resulted in a rapid and long-lasting decrease in the size of a whisker representation, and a decrease in the amplitude of the activity-dependent intrinsic signal. In contrast, NGF application resulted in a rapid but transient increase in the size of a representation, and an increase in the amplitude of the activity-dependent intrinsic signal. These results demonstrate that neurotrophins can rapidly modulate stimulus-dependent activity in adult cortex, and suggest a role for neurotrophins in regulating adult cortical plasticity.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Cohen Cory, Susana" sort="Cohen Cory, Susana" uniqKey="Cohen Cory S" first="Susana" last="Cohen-Cory">Susana Cohen-Cory</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Prakash, Neal" sort="Prakash, Neal" uniqKey="Prakash N" first="Neal" last="Prakash">Neal Prakash</name></noRegion><name sortKey="Frostig, Ron D" sort="Frostig, Ron D" uniqKey="Frostig R" first="Ron D." last="Frostig">Ron D. Frostig</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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